Addition of a single methyl group to a small molecule sodium channel inhibitor introduces a new mode of gating modulation

Por Wang, Lingxin, Zellmer, Shannon G., Printzenhoff, David M., Castle, Neil A.
Publicado no Br J Pharmacol (2015)

PF‐06526290 can both enhance and inhibit conduction through voltage‐gated sodium channels

Por Wang, Lingxin, Zellmer, Shannon G, Printzenhoff, David M, Castle, Neil A
Publicado no Br J Pharmacol (2018)

GI‐530159, a novel, selective, mechanosensitive two‐pore‐domain potassium (K(2P)) channel opener, reduces rat dorsal root ganglion neuron excitability

Por Loucif, Alexandre J C, Saintot, Pierre‐Philippe, Liu, Jia, Antonio, Brett M, Zellmer, Shannon G, Yoger, Katrina, Veale, Emma L, Wilbrey, Anna, Omoto, Kiyoyuki, Cao, Lishuang, Gutteridge, Alex, Castle, Neil A, Stevens, Edward B, Mathie, Alistair
Publicado no Br J Pharmacol (2017)

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors

Por Sammons, Matthew F., Kharade, Sujay V., Filipski, Kevin J., Boehm, Markus, Smith, Aaron C., Shavnya, Andre, Fernando, Dilinie P., Dowling, Matthew S., Carpino, Philip A., Castle, Neil A., Zellmer, Shannon G., Antonio, Brett M., Gosset, James R., Carlo, Anthony, Denton, Jerod S.
Publicado no ACS Med Chem Lett (2018)

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Por McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.
Publicado em 2013