PF‐06526290 can both enhance and inhibit conduction through voltage‐gated sodium channels

BACKGROUND AND PURPOSE: Pharmacological agents that either inhibit or enhance flux of ions through voltage‐gated sodium (Na(v)) channels may provide opportunities for treatment of human health disorders. During studies to characterize agents that modulate Na(v)1.3 function, we identified a compound...

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Bibliographic Details
Published in:Br J Pharmacol
Main Authors: Wang, Lingxin, Zellmer, Shannon G, Printzenhoff, David M, Castle, Neil A
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6016627/
https://ncbi.nlm.nih.gov/pubmed/29791744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14338
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