Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes

по Wu, Wen-Lian, Hao, Jinsong, Domalski, Martin, Burnett, Duane A., Pissarnitski, Dmitri, Zhao, Zhiqiang, Stamford, Andrew, Scapin, Giovanna, Gao, Ying-Duo, Soriano, Aileen, Kelly, Terri M., Yao, Zuliang, Powles, Mary Ann, Chen, Shiying, Mei, Hong, Hwa, Joyce
Опубликовано в: ACS Med Chem Lett (2016)

Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

по Blain, Jean-François, Bursavich, Matthew G., Freeman, Emily A., Hrdlicka, Lori A., Hodgdon, Hilliary E., Chen, Ting, Costa, Don E., Harrison, Bryce A., Kapadnis, Sudarshan, Murphy, Deirdre A., Nolan, Scott, Tu, Zhiming, Tang, Cuyue, Burnett, Duane A., Patzke, Holger, Koenig, Gerhard
Опубликовано в: Alzheimers Res Ther (2016)

Discovery of SCH 900229, a Potent Presenilin 1 Selective γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease

по Wu, Wen-Lian, Domalski, Martin, Burnett, Duane A., Josien, Hubert, Bara, Thomas, Rajagopalan, Murali, Xu, Ruo, Clader, John, Greenlee, William J., Brunskill, Andrew, Hyde, Lynn A., Del Vecchio, Robert A., Cohen-Williams, Mary E., Song, Lixin, Lee, Julie, Terracina, Giuseppe, Zhang, Qi, Nomeir, Amin, Parker, Eric M., Zhang, Lili
Опубликовано 2012

Synthesis and SAR Studies of Fused Oxadiazines as γ-Secretase Modulators for Treatment of Alzheimer's Disease

по Huang, Xianhai, Zhou, Wei, Liu, Xiaoxiang, Li, Hongmei, Sun, George, Mandal, Mihirbaran, Vicarel, Monica, Zhu, Xiaohong, Bennett, Chad, McCraken, Troy, Pissarnitski, Dmitri, Zhao, Zhiqiang, Cole, David, Gallo, Gioconda, Zhu, Zhaoning, Palani, Anandan, Aslanian, Robert, Clader, John, Czarniecki, Michael, Greenlee, William, Burnett, Duane, Cohen-Williams, Mary, Hyde, Lynn, Song, Lixin, Zhang, Lili, Chu, Inhou, Buevich, Alexei
Опубликовано 2012

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)

по Garcia-Calvo, Margarita, Lisnock, JeanMarie, Bull, Herbert G., Hawes, Brian E., Burnett, Duane A., Braun, Matthew P., Crona, James H., Davis, Harry R., Dean, Dennis C., Detmers, Patricia A., Graziano, Michael P., Hughes, Meredith, MacIntyre, D. Euan, Ogawa, Anthony, O'Neill, Kim A., Iyer, Sai Prasad N., Shevell, Diane E., Smith, Marsha M., Tang, Yui S., Makarewicz, Amanda M., Ujjainwalla, Feroze, Altmann, Scott W., Chapman, Kevin T., Thornberry, Nancy A.
Опубликовано 2005