GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

Por Lieu, T, Jayaweera, G, Bunnett, N W
Publicado em 2014

A25 COLONIC PROTEASES EVOKE SUSTAINED PAIN SIGNALING VIA A NOVEL ENDOSOMAL PATHWAY IN NEURONS

Por Jimenez-Vargas, N, Bunnett, N, Vanner, S
Publicado no J Can Assoc Gastroenterol (2018)

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors.

Por Böhm, S K, Grady, E F, Bunnett, N W
Publicado em 1997

Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells.

Por Okamoto, A, Lovett, M, Payan, D G, Bunnett, N W
Publicado em 1994

A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS

Por Jiménez-Vargas, N N, Reed, D E, Bunnett, N, Vanner, S
Publicado no J Can Assoc Gastroenterol (2018)

A role for calcitonin gene-related peptide in protection against gastric ulceration.

Por Gray, J L, Bunnett, N W, Orloff, S L, Mulvihill, S J, Debas, H T
Publicado em 1994

Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.

Por Garland, A M, Grady, E F, Payan, D G, Vigna, S R, Bunnett, N W
Publicado em 1994

β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2

Por DeFea, K.A., Zalevsky, J., Thoma, M.S., Déry, O., Mullins, R.D., Bunnett, N.W.
Publicado em 2000

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

Por Grace, M S, Lieu, T, Darby, B, Abogadie, F C, Veldhuis, N, Bunnett, N W, McIntyre, P
Publicado em 2014

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

Por Grady, E F, Garland, A M, Gamp, P D, Lovett, M, Payan, D G, Bunnett, N W
Publicado em 1995

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex

Por DeFea, K. A., Vaughn, Z. D., O'Bryan, E. M., Nishijima, D., Déry, O., Bunnett, N. W.
Publicado em 2000

A213 A NOVEL PH-SENSITIVE OPIOID ANALGESIC THAT IS SELECTIVELY ACTIVATED IN ACIDIC INFLAMMATORY ENVIRONMENTS

Por Yu, Y, Jiménez-Vargas, N N, Lopez Lopez, C D, Jaramillo Polanco, J O, Bunnett, N W, Vanner, S
Publicado no J Can Assoc Gastroenterol (2020)

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

Por Sternini, C, Spann, M, Anton, B, Keith, D E, Bunnett, N W, von Zastrow, M, Evans, C, Brecha, N C
Publicado em 1996

ACTIVATION AND INTERNALIZATION OF THE μ-OPIOID RECEPTOR BY THE NEWLY DISCOVERED ENDOGENOUS AGONISTS, ENDOMORPHIN-1 AND ENDOMORPHIN-2

Por McCONALOGUE, K., GRADY, E. F., MINNIS, J., BALESTRA, B., TONINI, M., BRECHA, N. C., BUNNETT, N. W., STERNINI, C.
Publicado no Neuroscience (1999)

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P

Por Sturiale, S., Barbara, G., Qiu, B., Figini, M., Geppetti, P., Gerard, N., Gerard, C., Grady, E. F., Bunnett, N. W., Collins, S. M.
Publicado em 1999

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.

Por Bowden, J J, Garland, A M, Baluk, P, Lefevre, P, Grady, E F, Vigna, S R, Bunnett, N W, McDonald, D M
Publicado em 1994

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

Por Corvera, C U, Déry, O, McConalogue, K, Böhm, S K, Khitin, L M, Caughey, G H, Payan, D G, Bunnett, N W
Publicado em 1997

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants

Por Cattaruzza, F, Amadesi, S, Carlsson, J F, Murphy, J E, Lyo, V, Kirkwood, K, Cottrell, G S, Bogyo, M, Knecht, W, Bunnett, N W
Publicado em 2014

A201 ENDOGENOUS OPIOIDS AND NANOPARTICLES TARGETING SIGNALING FROM DELTA OPIOID RECEPTORS IN ENDOSOMES INDUCE SUSTAINED INHIBITION OF NOCICEPTIVE AFFERENT NERVES INNERVATING THE IN...

Por Jiménez-Vargas, N N, Yu, Y, Jaramillo Polanco, J O, Lopez Lopez, C D, Gong, J, Schmidt, B L, Bunnett, N W, Vanner, S
Publicado no J Can Assoc Gastroenterol (2020)

Canine bombesin-like gastrin releasing peptides stimulate gastrin release and acid secretion in the dog.

Por Bunnett, N W, Clark, B, Debas, H T, Del Milton, R C, Kovacs, T O, Orloff, M S, Pappas, T N, Reeve, J R, Rivier, J E, Walsh, J H
Publicado em 1985