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A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS
BACKGROUND: Patients suffering from the irritable bowel syndrome report exaggerated and sustained abdominal pain. We have shown that activation of protease activated receptor 2 (PAR2) on nociceptive (pain sensing) dorsal root ganglia (DRG) neurons evoke long term hyperexcitability but the mechanisms...
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| Pubblicato in: | J Can Assoc Gastroenterol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6507927/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy008.314 |
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