A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS

BACKGROUND: Patients suffering from the irritable bowel syndrome report exaggerated and sustained abdominal pain. We have shown that activation of protease activated receptor 2 (PAR2) on nociceptive (pain sensing) dorsal root ganglia (DRG) neurons evoke long term hyperexcitability but the mechanisms...

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Detalhes bibliográficos
Publicado no:J Can Assoc Gastroenterol
Main Authors: Jiménez-Vargas, N N, Reed, D E, Bunnett, N, Vanner, S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Poster Presentations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6507927/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy008.314
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