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A25 COLONIC PROTEASES EVOKE SUSTAINED PAIN SIGNALING VIA A NOVEL ENDOSOMAL PATHWAY IN NEURONS
BACKGROUND: Proteases are increased in IBS patient colonic tissue and have been shown to activate and sensitize nociceptive (pain-sensing) dorsal root ganglia (DRG) neurons. We found that activation of protease activated receptor 2 (PAR2) on DRG neurons leads to prolonged pain signaling (> 1h). S...
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| 發表在: | J Can Assoc Gastroenterol |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6508351/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy009.025 |
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