A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS

BACKGROUND: Endogenous opioids released from CD4+T cells are increased in inflammatory bowel disease patients (IBD) and pre-clinical models of IBD, and have an important analgesic effect. We have shown that endogenous opioids in supernatant from cDSS mice have an antinociceptive action on dorsal roo...

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Bibliografske podrobnosti
izdano v:J Can Assoc Gastroenterol
Main Authors: Jiménez-Vargas, N N, Rajasekhar, P, Yeatman, H R, Canals, M, Bunnett, N, Poole, D P, Halls, M L, Reed, D E, Lomax, A E, Vanner, S
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2019
Teme:
Posters Of Distinction
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512542/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.026
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