A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS

BACKGROUND: Endogenous opioids released from CD4+T cells are increased in inflammatory bowel disease patients (IBD) and pre-clinical models of IBD, and have an important analgesic effect. We have shown that endogenous opioids in supernatant from cDSS mice have an antinociceptive action on dorsal roo...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Can Assoc Gastroenterol
Main Authors: Jiménez-Vargas, N N, Rajasekhar, P, Yeatman, H R, Canals, M, Bunnett, N, Poole, D P, Halls, M L, Reed, D E, Lomax, A E, Vanner, S
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Posters Of Distinction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512542/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.026
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares