A27 THE SUSTAINED ANTINOCICEPTIVE EFFECT OF ENDOGENOUS OPIOIDS IN PRECLINICAL MODEL OF IBD IS MEDIATED BY COMPARTMENTALIZED ENDOSOMAL SIGNALING BY DELTA OPIOID RECEPTORS

BACKGROUND: Endogenous opioids released from CD4+T cells are increased in inflammatory bowel disease patients (IBD) and pre-clinical models of IBD, and have an important analgesic effect. We have shown that endogenous opioids in supernatant from cDSS mice have an antinociceptive action on dorsal roo...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Can Assoc Gastroenterol
Prif Awduron: Jiménez-Vargas, N N, Rajasekhar, P, Yeatman, H R, Canals, M, Bunnett, N, Poole, D P, Halls, M L, Reed, D E, Lomax, A E, Vanner, S
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2019
Pynciau:
Posters Of Distinction
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512542/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwz006.026
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