Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Whether G protein-coupled receptors signal from endosomes to control important pathophysiological processes and are therapeutic targets is uncertain. We report that opioids from the inflamed colon activate δ-opioid receptors (DOPr) in endosomes of nociceptors. Biopsy samples of inflamed colonic muco...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Jimenez-Vargas, Nestor N., Gong, Jing, Wisdom, Matthew J., Jensen, Dane D., Latorre, Rocco, Hegron, Alan, Teng, Shavonne, DiCello, Jesse J., Rajasekhar, Pradeep, Veldhuis, Nicholas A., Carbone, Simona E., Yu, Yang, Lopez-Lopez, Cintya, Jaramillo-Polanco, Josue, Canals, Meritxell, Reed, David E., Lomax, Alan E., Schmidt, Brian L., Leong, Kam W., Vanner, Stephen J., Halls, Michelle L., Bunnett, Nigel W., Poole, Daniel P.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334524/
https://ncbi.nlm.nih.gov/pubmed/32546520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2000500117
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