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A25 COLONIC PROTEASES EVOKE SUSTAINED PAIN SIGNALING VIA A NOVEL ENDOSOMAL PATHWAY IN NEURONS

BACKGROUND: Proteases are increased in IBS patient colonic tissue and have been shown to activate and sensitize nociceptive (pain-sensing) dorsal root ganglia (DRG) neurons. We found that activation of protease activated receptor 2 (PAR2) on DRG neurons leads to prolonged pain signaling (> 1h). S...

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Bibliografiske detaljer
Udgivet i:J Can Assoc Gastroenterol
Main Authors: Jimenez-Vargas, N, Bunnett, N, Vanner, S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508351/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jcag/gwy009.025
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