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Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.

Substance P (SP) can cause plasma leakage at sites of inflammation by binding to neurokinin type 1 (NK1) receptors on the surface of endothelial cells. Internalization after ligand binding could reduce the number of NK1 receptors on the cell surface and thus participate in the desensitization and re...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bowden, J J, Garland, A M, Baluk, P, Lefevre, P, Grady, E F, Vigna, S R, Bunnett, N W, McDonald, D M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1994
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44727/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7522326/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.19.8964
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