Clinical Development of Listeria monocytogenes–Based Immunotherapies

由 Le, Dung T., Dubensky, Thomas W., Brockstedt, Dirk G.
出版 2012

Radiation therapy combined with Listeria monocytogenes-based cancer vaccine synergize to enhance tumor control in the B16 melanoma model

由 Lim, Joanne YH, Brockstedt, Dirk G, Lord, Edith M, Gerber, Scott A
出版 2014

Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes

由 Auerbuch, Victoria, Brockstedt, Dirk G., Meyer-Morse, Nicole, O'Riordan, Mary, Portnoy, Daniel A.
出版 2004

Clinical experience with live-attenuated, double-deleted (LADD) listeria monocytogenes targeting mesothelin-expressing tumors

由 Brockstedt, Dirk G, Le, Dung T, Hassan, Raffit, Murphy, Aimee, Grous, John, Dubensky, Thomas W, Jaffee, Elizabeth M
出版 2013

Cytosolic Entry Controls CD8(+)-T-Cell Potency during Bacterial Infection

由 Bahjat, Keith S., Liu, Weiqun, Lemmens, Edward E., Schoenberger, Stephen P., Portnoy, Daniel A., Dubensky, Thomas W., Brockstedt, Dirk G.
出版 2006

Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies...

由 Leong, Meredith L., Hampl, Johannes, Liu, Weiqun, Mathur, Shruti, Bahjat, Keith S., Luckett, William, Dubensky, Thomas W., Brockstedt, Dirk G.
出版 2009

Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria

由 Bahjat, Keith S., Meyer-Morse, Nicole, Lemmens, Edward E., Shugart, Jessica A., Dubensky, Thomas W., Brockstedt, Dirk G., Portnoy, Daniel A.
出版 2009

Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis

由 Lizotte, Patrick H, Baird, Jason R, Stevens, Cynthia A, Lauer, Peter, Green, William R, Brockstedt, Dirk G, Fiering, Steven N
出版 2014

Enhanced Virus-Specific CD8(+) T Cell Responses by Listeria monocytogenes-Infected Dendritic Cells in the Context of Tim-3 Blockade

由 Ma, Cheng J., Ren, Jun P., Li, Guang Y., Wu, Xiao Y., Brockstedt, Dirk G., Lauer, Peter, Moorman, Jonathan P., Yao, Zhi Q.
出版 2014

Anti-mesothelin vaccine CRS-207 with or without low-dose cyclophosphamide plus chemotherapy as front-line treatment for malignant pleural mesothelioma (MPM)

由 Hassan, Raffit, Alley, Evan, Kindler, Hedy, Antonia, Scott, Jahan, Thierry, Thomas, Anish, Honarmand, Somayeh, Murphy, Aimee L, Grous, John J, Brockstedt, Dirk G
發表在 J Immunother Cancer (2015)

Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer

由 Nair, Nitya, Chen, Shih-Yu, Lemmens, Ed, Chang, Serena, Le, Dung T., Jaffee, Elizabeth M., Murphy, Aimee, Whiting, Chan, Müller, Thomas, Brockstedt, Dirk G.
發表在 Cancer Immunol Res (2020)

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

由 Skoberne, Mojca, Yewdall, Alice, Bahjat, Keith S., Godefroy, Emmanuelle, Lauer, Peter, Lemmens, Edward, Liu, Weiqun, Luckett, Will, Leong, Meredith, Dubensky, Thomas W., Brockstedt, Dirk G., Bhardwaj, Nina
出版 2008

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

由 Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, Liu, Weiqun, Cook, David N., Portnoy, Daniel A., Dubensky, Thomas W.
出版 2004

Phase I study of safety and immunogenicity of ADU-623, a live-attenuated listeria monocytogenes vaccine (ΔactA/ΔinlB) expressing EGFRVIII and NY-ESO-1, in patients with who grade I...

由 Crittenden, Marka, Bahjat, Keith S, Li, Rui, Gore, Pankaj, Fountain, Chris, Hanson, Bill, Skoble, Justin, Lauer, Peter, Murphy, Aimee L, Dubensky, Thomas, Brockstedt, Dirk G, Urba, Walter
發表在 J Immunother Cancer (2015)

Long term survivors and immune biomarker analysis of Phase IIa, randomized study of GVAX pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer

由 Nair, Nitya, Lemmens, Ed, Enstrom, Amanda, Chen, Shih-Yu, Chang, Serena, Le, Dung, Jaffee, Elizabeth M, Maecker, Holden, Murphy, Aimee L, Brockstedt, Dirk G, Whiting, Chan
發表在 J Immunother Cancer (2015)

Attenuated Listeria monocytogenes Vectors Overcome Suppressive Plasma Factors During HIV Infection to Stimulate Myeloid Dendritic Cells to Promote Adaptive Immunity and Reactivatio...

由 Miller, Elizabeth A., Spadaccia, Meredith R., Norton, Thomas, Demmler, Morgan, Gopal, Ramya, O'Brien, Meagan, Landau, Nathaniel, Dubensky, Thomas W., Lauer, Peter, Brockstedt, Dirk G., Bhardwaj, Nina
發表在 AIDS Res Hum Retroviruses (2015)

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains

由 Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., Allen, Heather E., Skoble, Justin, Bahjat, Keith S., Freitag, Nancy E., Brockstedt, Dirk G., Dubensky, Thomas W.
出版 2008

A Potent and Effective Suicidal Listeria Vaccine Platform

由 Hanson, William G., Benanti, Erin L., Lemmens, Edward E., Liu, Weiqun, Skoble, Justin, Leong, Meredith L., Rae, Chris S., Fassò, Marcella, Brockstedt, Dirk G., Chen, Chen, Portnoy, Daniel A., Dubensky, Thomas W., Lauer, Peter
發表在 Infect Immun (2019)

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

由 Schietinger, Andrea, Philip, Mary, Krisnawan, Varintra E., Chiu, Edison Y., Delrow, Jeffrey J., Basom, Ryan S., Lauer, Peter, Brockstedt, Dirk G., Knoblaugh, Sue E., Hämmerling, Günter J., Schell, Todd D., Garbi, Natalio, Greenberg, Philip D.
發表在 Immunity (2016)

A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

由 Keenan, Bridget P., Saenger, Yvonne, Kafrouni, Michel I., Leubner, Ashley, Lauer, Peter, Maitra, Anirban, Rucki, Agnieszka A., Gunderson, Andrew J., Coussens, Lisa M., Brockstedt, Dirk G., Dubensky, Thomas W., Hassan, Raffit, Armstrong, Todd D., Jaffee, Elizabeth M.
出版 2014