Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains

Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort has been stimulated in part due to preclinical results that illustrate potent activation of innate and...

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Bibliografiske detaljer
Main Authors: Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., Allen, Heather E., Skoble, Justin, Bahjat, Keith S., Freitag, Nancy E., Brockstedt, Dirk G., Dubensky, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493200/
https://ncbi.nlm.nih.gov/pubmed/18541651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00390-08
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