Clinical Development of Listeria monocytogenes–Based Immunotherapies

por Le, Dung T., Dubensky, Thomas W., Brockstedt, Dirk G.
Publicado 2012

Radiation therapy combined with Listeria monocytogenes-based cancer vaccine synergize to enhance tumor control in the B16 melanoma model

por Lim, Joanne YH, Brockstedt, Dirk G, Lord, Edith M, Gerber, Scott A
Publicado 2014

Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes

por Auerbuch, Victoria, Brockstedt, Dirk G., Meyer-Morse, Nicole, O'Riordan, Mary, Portnoy, Daniel A.
Publicado 2004

Clinical experience with live-attenuated, double-deleted (LADD) listeria monocytogenes targeting mesothelin-expressing tumors

por Brockstedt, Dirk G, Le, Dung T, Hassan, Raffit, Murphy, Aimee, Grous, John, Dubensky, Thomas W, Jaffee, Elizabeth M
Publicado 2013

Cytosolic Entry Controls CD8(+)-T-Cell Potency during Bacterial Infection

por Bahjat, Keith S., Liu, Weiqun, Lemmens, Edward E., Schoenberger, Stephen P., Portnoy, Daniel A., Dubensky, Thomas W., Brockstedt, Dirk G.
Publicado 2006

Impact of Preexisting Vector-Specific Immunity on Vaccine Potency: Characterization of Listeria monocytogenes-Specific Humoral and Cellular Immunity in Humans and Modeling Studies...

por Leong, Meredith L., Hampl, Johannes, Liu, Weiqun, Mathur, Shruti, Bahjat, Keith S., Luckett, William, Dubensky, Thomas W., Brockstedt, Dirk G.
Publicado 2009

Suppression of Cell-Mediated Immunity following Recognition of Phagosome-Confined Bacteria

por Bahjat, Keith S., Meyer-Morse, Nicole, Lemmens, Edward E., Shugart, Jessica A., Dubensky, Thomas W., Brockstedt, Dirk G., Portnoy, Daniel A.
Publicado 2009

Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis

por Lizotte, Patrick H, Baird, Jason R, Stevens, Cynthia A, Lauer, Peter, Green, William R, Brockstedt, Dirk G, Fiering, Steven N
Publicado 2014

Enhanced Virus-Specific CD8(+) T Cell Responses by Listeria monocytogenes-Infected Dendritic Cells in the Context of Tim-3 Blockade

por Ma, Cheng J., Ren, Jun P., Li, Guang Y., Wu, Xiao Y., Brockstedt, Dirk G., Lauer, Peter, Moorman, Jonathan P., Yao, Zhi Q.
Publicado 2014

Anti-mesothelin vaccine CRS-207 with or without low-dose cyclophosphamide plus chemotherapy as front-line treatment for malignant pleural mesothelioma (MPM)

por Hassan, Raffit, Alley, Evan, Kindler, Hedy, Antonia, Scott, Jahan, Thierry, Thomas, Anish, Honarmand, Somayeh, Murphy, Aimee L, Grous, John J, Brockstedt, Dirk G
Publicado en J Immunother Cancer (2015)

Single-Cell Immune Competency Signatures Associate with Survival in Phase II GVAX and CRS-207 Randomized Studies in Patients with Metastatic Pancreatic Cancer

por Nair, Nitya, Chen, Shih-Yu, Lemmens, Ed, Chang, Serena, Le, Dung T., Jaffee, Elizabeth M., Murphy, Aimee, Whiting, Chan, Müller, Thomas, Brockstedt, Dirk G.
Publicado en Cancer Immunol Res (2020)

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

por Skoberne, Mojca, Yewdall, Alice, Bahjat, Keith S., Godefroy, Emmanuelle, Lauer, Peter, Lemmens, Edward, Liu, Weiqun, Luckett, Will, Leong, Meredith, Dubensky, Thomas W., Brockstedt, Dirk G., Bhardwaj, Nina
Publicado 2008

Listeria-based cancer vaccines that segregate immunogenicity from toxicity

por Brockstedt, Dirk G., Giedlin, Martin A., Leong, Meredith L., Bahjat, Keith S., Gao, Yi, Luckett, William, Liu, Weiqun, Cook, David N., Portnoy, Daniel A., Dubensky, Thomas W.
Publicado 2004

Phase I study of safety and immunogenicity of ADU-623, a live-attenuated listeria monocytogenes vaccine (ΔactA/ΔinlB) expressing EGFRVIII and NY-ESO-1, in patients with who grade I...

por Crittenden, Marka, Bahjat, Keith S, Li, Rui, Gore, Pankaj, Fountain, Chris, Hanson, Bill, Skoble, Justin, Lauer, Peter, Murphy, Aimee L, Dubensky, Thomas, Brockstedt, Dirk G, Urba, Walter
Publicado en J Immunother Cancer (2015)

Long term survivors and immune biomarker analysis of Phase IIa, randomized study of GVAX pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer

por Nair, Nitya, Lemmens, Ed, Enstrom, Amanda, Chen, Shih-Yu, Chang, Serena, Le, Dung, Jaffee, Elizabeth M, Maecker, Holden, Murphy, Aimee L, Brockstedt, Dirk G, Whiting, Chan
Publicado en J Immunother Cancer (2015)

Attenuated Listeria monocytogenes Vectors Overcome Suppressive Plasma Factors During HIV Infection to Stimulate Myeloid Dendritic Cells to Promote Adaptive Immunity and Reactivatio...

por Miller, Elizabeth A., Spadaccia, Meredith R., Norton, Thomas, Demmler, Morgan, Gopal, Ramya, O'Brien, Meagan, Landau, Nathaniel, Dubensky, Thomas W., Lauer, Peter, Brockstedt, Dirk G., Bhardwaj, Nina
Publicado en AIDS Res Hum Retroviruses (2015)

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains

por Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., Allen, Heather E., Skoble, Justin, Bahjat, Keith S., Freitag, Nancy E., Brockstedt, Dirk G., Dubensky, Thomas W.
Publicado 2008

A Potent and Effective Suicidal Listeria Vaccine Platform

por Hanson, William G., Benanti, Erin L., Lemmens, Edward E., Liu, Weiqun, Skoble, Justin, Leong, Meredith L., Rae, Chris S., Fassò, Marcella, Brockstedt, Dirk G., Chen, Chen, Portnoy, Daniel A., Dubensky, Thomas W., Lauer, Peter
Publicado en Infect Immun (2019)

Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

por Schietinger, Andrea, Philip, Mary, Krisnawan, Varintra E., Chiu, Edison Y., Delrow, Jeffrey J., Basom, Ryan S., Lauer, Peter, Brockstedt, Dirk G., Knoblaugh, Sue E., Hämmerling, Günter J., Schell, Todd D., Garbi, Natalio, Greenberg, Philip D.
Publicado en Immunity (2016)

A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

por Keenan, Bridget P., Saenger, Yvonne, Kafrouni, Michel I., Leubner, Ashley, Lauer, Peter, Maitra, Anirban, Rucki, Agnieszka A., Gunderson, Andrew J., Coussens, Lisa M., Brockstedt, Dirk G., Dubensky, Thomas W., Hassan, Raffit, Armstrong, Todd D., Jaffee, Elizabeth M.
Publicado 2014