A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

BACKGROUND & AIMS: Premalignant lesions and early stage tumors contain immunosuppressive microenvironments that create barriers for cancer vaccines. Kras(G12D/+);Trp53(R172H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pancreatic intraepithelial...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Keenan, Bridget P., Saenger, Yvonne, Kafrouni, Michel I., Leubner, Ashley, Lauer, Peter, Maitra, Anirban, Rucki, Agnieszka A., Gunderson, Andrew J., Coussens, Lisa M., Brockstedt, Dirk G., Dubensky, Thomas W., Hassan, Raffit, Armstrong, Todd D., Jaffee, Elizabeth M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035450/
https://ncbi.nlm.nih.gov/pubmed/24607504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.02.055
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