A Listeria Vaccine and Depletion of T-Regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice

BACKGROUND & AIMS: Premalignant lesions and early stage tumors contain immunosuppressive microenvironments that create barriers for cancer vaccines. Kras(G12D/+);Trp53(R172H/+);Pdx-1-Cre (KPC) mice, which express an activated form of Kras in pancreatic tissues, develop pancreatic intraepithelial...

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Detalhes bibliográficos
Main Authors: Keenan, Bridget P., Saenger, Yvonne, Kafrouni, Michel I., Leubner, Ashley, Lauer, Peter, Maitra, Anirban, Rucki, Agnieszka A., Gunderson, Andrew J., Coussens, Lisa M., Brockstedt, Dirk G., Dubensky, Thomas W., Hassan, Raffit, Armstrong, Todd D., Jaffee, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035450/
https://ncbi.nlm.nih.gov/pubmed/24607504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.02.055
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