Exhaustion of cytotoxic effector systems may limit mAb-based immunotherapy in cancer patients()

Por Beurskens, Frank J., Lindorfer, Margaret A., Farooqui, Mohammed, Beum, Paul V., Engelberts, Patrick, Mackus, Wendy J.M., Parren, Paul W.H.I., Wiestner, Adrian, Taylor, Ronald P.
Publicado em 2012

Ibrutinib interferes with the cell-mediated anti-tumor activities of therapeutic CD20 antibodies: implications for combination therapy

Por Roit, Fabio Da, Engelberts, Patrick J., Taylor, Ronald P., Breij, Esther C.W., Gritti, Giuseppe, Rambaldi, Alessandro, Introna, Martino, Parren, Paul W.H.I., Beurskens, Frank J., Golay, Josée
Publicado no Haematologica (2015)

Antibodies That Efficiently Form Hexamers upon Antigen Binding Can Induce Complement-Dependent Cytotoxicity under Complement-Limiting Conditions

Por Cook, Erika M., Lindorfer, Margaret A., van der Horst, Hilma, Oostindie, Simone, Beurskens, Frank J., Schuurman, Janine, Zent, Clive S., Burack, Richard, Parren, Paul W. H. I., Taylor, Ronald P.
Publicado no J Immunol (2016)

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

Por Boross, Peter, Jansen, J.H. Marco, de Haij, Simone, Beurskens, Frank J., van der Poel, Cees E., Bevaart, Lisette, Nederend, Maaike, Golay, Josée, van de Winkel, Jan G.J., Parren, Paul W.H.I., Leusen, Jeanette H.W.
Publicado em 2011

Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activation

Por van den Bremer, Ewald TJ, Beurskens, Frank J, Voorhorst, Marleen, Engelberts, Patrick J, de Jong, Rob N, van der Boom, Burt G, Cook, Erika M, Lindorfer, Margaret A, Taylor, Ronald P, van Berkel, Patrick HC, Parren, Paul WHI
Publicado no MAbs (2015)

A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface

Por de Jong, Rob N., Beurskens, Frank J., Verploegen, Sandra, Strumane, Kristin, van Kampen, Muriel D., Voorhorst, Marleen, Horstman, Wendy, Engelberts, Patrick J., Oostindie, Simone C., Wang, Guanbo, Heck, Albert J. R., Schuurman, Janine, Parren, Paul W. H. I.
Publicado no PLoS Biol (2016)

Resolution of psoriasis upon blockade of IL-15 biological activity in a xenograft mouse model

Por Villadsen, Louise S., Schuurman, Janine, Beurskens, Frank, Dam, Tomas N., Dagnæs-Hansen, Frederik, Skov, Lone, Rygaard, Jørgen, Voorhorst-Ogink, Marleen M., Gerritsen, Arnout F., van Dijk, Marc A., Parren, Paul W.H.I., Baadsgaard, Ole, van de Winkel, Jan G.J.
Publicado em 2003

Hinge-deleted IgG4 blocker therapy for acetylcholine receptor myasthenia gravis in rhesus monkeys

Por Losen, Mario, Labrijn, Aran F., van Kranen-Mastenbroek, Vivianne H., Janmaat, Maarten L., Haanstra, Krista G., Beurskens, Frank J., Vink, Tom, Jonker, Margreet, ‘t Hart, Bert A., Mané-Damas, Marina, Molenaar, Peter C., Martinez-Martinez, Pilar, van der Esch, Eline, Schuurman, Janine, de Baets, Marc H., Parren, Paul W. H. I.
Publicado no Sci Rep (2017)

Complement Is Activated by IgG Hexamers Assembled at the Cell Surface

Por Diebolder, Christoph A., Beurskens, Frank J., de Jong, Rob N., Koning, Roman I., Strumane, Kristin, Lindorfer, Margaret A., Voorhorst, Marleen, Ugurlar, Deniz, Rosati, Sara, Heck, Albert J. R., van de Winkel, Jan G. J., Wilson, Ian A., Koster, Abraham J., Taylor, Ronald P., Saphire, Erica Ollmann, Burton, Dennis R., Schuurman, Janine, Gros, Piet, Parren, Paul W. H. I.
Publicado no Science (2014)