Tumor derived TGF-Beta mediates conversion of CD4+Foxp3+ regulatory T cells in a murine model of pancreas cancer

gan Moo-Young, Tricia A., Larson, Justin W., Belt, Brian A., Tan, Marcus C., Hawkins, William G., Eberlein, Timothy J., Goedegebuure, Peter S., Linehan, David C.
Cyhoeddwyd 2009

Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes

gan Connolly, Kelli A., Belt, Brian A., Figueroa, Nathania M., Murthy, Aditi, Patel, Ankit, Kim, Minsoo, Lord, Edith M., Linehan, David C., Gerber, Scott A.
Cyhoeddwyd yn Oncotarget (2016)

Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth

gan Porembka, Matthew R., Mitchem, Jonathan B., Belt, Brian A., Hsieh, Chyi-Song, Lee, Hyang-Mi, Herndon, John, Gillanders, William E., Linehan, David C., Goedegebuure, Peter
Cyhoeddwyd 2012

Disruption of CCR5-dependent homing of regulatory T cells inhibits tumor growth in a murine model of pancreatic cancer

gan Tan, Marcus C. B., Goedegebuure, Peter S., Belt, Brian A., Flaherty, Brian, Sankpal, Narendra, Gillanders, William E., Eberlein, Timothy J., Hsieh, Chyi-Song, Linehan, David C.
Cyhoeddwyd 2009

Cross-dressed CD8α(+)/CD103(+) dendritic cells prime CD8(+) T cells following vaccination

gan Li, Lijin, Kim, Sojung, Herndon, John M., Goedegebuure, Peter, Belt, Brian A., Satpathy, Ansuman T., Fleming, Timothy P., Hansen, Ted H., Murphy, Kenneth M., Gillanders, William E.
Cyhoeddwyd 2012

INDUCTION OF TH17 CELLS IN THE TUMOR MICROENVIRONMENT IMPROVES SURVIVAL IN A MURINE MODEL OF PANCREATIC CANCER

gan Gnerlich, Jennifer L., Mitchem, Jonathan B., Weir, Joshua S., Sankpal, Narendra V., Kashiwagi, Hiroyuki, Belt, Brian A., Herndon, John M., Eberlein, Timothy J., Goedegebuure, Peter, Linehan, David C.
Cyhoeddwyd 2010

Recruitment of CCR2(+) tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

gan Grossman, Julie G, Nywening, Timothy M, Belt, Brian A, Panni, Roheena Z, Krasnick, Bradley A, DeNardo, David G, Hawkins, William G, Goedegebuure, S Peter, Linehan, David C, Fields, Ryan C
Cyhoeddwyd yn Oncoimmunology (2018)

Assessing the magnitude of immunogenic cell death following chemotherapy and irradiation reveals a new strategy to treat pancreatic cancer

gan Ye, Jian, Mills, Bradley N., Zhao, Tony, Han, Booyeon J., Murphy, Joseph D., Patel, Ankit P., Johnston, Carl J., Lord, Edith M., Belt, Brian A., Linehan, David C., Gerber, Scott A.
Cyhoeddwyd yn Cancer Immunol Res (2019)

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

gan Panni, Roheena Z., Sanford, Dominic E., Belt, Brian A., Mitchem, Jonathan B., Worley, Lori A., Goetz, Brian D., Mukherjee, Pinku, Wang-Gillam, Andrea, Link, Daniel C., DeNardo, David G., Goedegebuure, S. Peter, Linehan, David C.
Cyhoeddwyd 2014

Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma

gan Han, Booyeon J., Murphy, Joseph D., Qin, Shuyang, Ye, Jian, Uccello, Taylor P., Garrett-Larsen, Jesse, Belt, Brian A., Prieto, Peter A., Egilmez, Nejat K., Lord, Edith M., Linehan, David C., Mills, Bradley N., Gerber, Scott A.
Cyhoeddwyd yn Immunol Invest (2020)

Phase 1b study of a small molecule antagonist of human chemokine (C-C motif) receptor 2 (PF-04136309) in combination with nab-paclitaxel/gemcitabine in first-line treatment of meta...

gan Noel, Marcus, O’Reilly, Eileen M., Wolpin, Brian M., Ryan, David P., Bullock, Andrea J., Britten, Carolyn D., Linehan, David C., Belt, Brian A., Gamelin, Eric C., Ganguly, Bishu, Yin, Donghua, Joh, Tenshang, Jacobs, Ira A., Taylor, Carrie T., Lowery, Maeve A.
Cyhoeddwyd yn Invest New Drugs (2019)

Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2/CCR2 axis

gan Sanford, Dominic E., Belt, Brian A., Panni, Roheena Z., Mayer, Allese, Deshpande, Anjali D., Carpenter, Danielle, Mitchem, Jonathan B., Plambeck-Suess, Stacey M., Worley, Lori A., Goetz, Brian D., Wang-Gillam, Andrea, Eberlein, Timothy J., Denardo, David G., Goedegebuure, S. Peter, Linehan, David C.
Cyhoeddwyd 2013

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis

gan Ruhland, Megan K., Loza, Andrew J., Capietto, Aude-Helene, Luo, Xianmin, Knolhoff, Brett L., Flanagan, Kevin C., Belt, Brian A., Alspach, Elise, Leahy, Kathleen, Luo, Jingqin, Schaffer, Andras, Edwards, John R., Longmore, Gregory, Faccio, Roberta, DeNardo, David G., Stewart, Sheila A.
Cyhoeddwyd yn Nat Commun (2016)

Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcino...

gan Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Cyhoeddwyd yn Gut (2018)

A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma

gan Sanford, Dominic E., Porembka, Matthew R., Panni, Roheena Z., Mitchem, Jonathan B., Belt, Brian A., Plambeck-Suess, Stacey M., Lin, Goldie, DeNardo, David G., Fields, Ryan C., Hawkins, William G., Strasberg, Steven M., Lockhart, A. Craig, Wang-Gillam, Andrea, Goedegebuure, Simon Peter, Linehan, David C.
Cyhoeddwyd 2013

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic responses

gan Mitchem, Jonathan B., Brennan, Donal J., Knolhoff, Brett L., Belt, Brian A., Zhu, Yu, Sanford, Dominic E., Belaygorod, Larisa, Carpenter, Danielle, Collins, Lynne, Piwnica-Worms, David, Hewitt, Stephen, Udupi, Girish Mallya, Gallagher, William M., Wegner, Craig, West, Brian L., Wang-Gillam, Andrea, Goedegebuure, S Peter, Linehan, David C., DeNardo, David G.
Cyhoeddwyd 2012

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

gan Mills, Bradley N., Connolly, Kelli A., Ye, Jian, Murphy, Joseph D., Uccello, Taylor P., Han, Booyeon J., Zhao, Tony, Drage, Michael G., Murthy, Aditi, Qiu, Haoming, Patel, Ankit, Figueroa, Nathania M., Johnston, Carl J., Prieto, Peter A., Egilmez, Nejat K., Belt, Brian A., Lord, Edith M., Linehan, David C., Gerber, Scott A.
Cyhoeddwyd yn Cell Rep (2019)

Purity Independent Subtyping of Tumors (PurIST), a clinically robust, single sample classifier for tumor subtyping in pancreatic cancer

gan Rashid, Naim U, Peng, Xianlu L., Jin, Chong, Moffitt, Richard A., Volmar, Keith E., Belt, Brian A., Panni, Roheena Z., Nywening, Timothy M., Herrera, Silvia G., Moore, Kristin J., Hennessey, Sarah, Morrison, Ashley B., Kawalerski, Ryan, Nayyar, Apoorve, Chang, Audrey E., Schmidt, Benjamin, Kim, Hong Jin, Linehan, David C., Yeh, Jen Jen
Cyhoeddwyd yn Clin Cancer Res (2019)

Phase 1b study targeting tumour associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer

gan Nywening, Timothy M, Wang-Gillam, Andrea, Sanford, Dominic E, Belt, Brian A, Panni, Roheena Z, Cusworth, Brian M, Toriola, Adetunji T, Nieman, Rebecca K, Worley, Lori A, Yano, Motoyo, Fowler, Kathryn J, Lockhart, A Craig, Suresh, Rama, Tan, Benjamin R, Lim, Kian-Huat, Fields, Ryan C, Strasberg, Steven M, Hawkins, William G, DeNardo, David G, Goedegebuure, S Peter, Linehan, David C
Cyhoeddwyd yn Lancet Oncol (2016)