Recruitment of CCR2(+) tumor associated macrophage to sites of liver metastasis confers a poor prognosis in human colorectal cancer

The tumor microenvironment (TME) represents a significant barrier to creating effective therapies for metastatic colorectal cancer (mCRC). In several malignancies, bone marrow derived CCR2(+) inflammatory monocytes (IM) are recruited to the TME by neoplastic cells, where they become immunosuppressiv...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Grossman, Julie G, Nywening, Timothy M, Belt, Brian A, Panni, Roheena Z, Krasnick, Bradley A, DeNardo, David G, Hawkins, William G, Goedegebuure, S Peter, Linehan, David C, Fields, Ryan C
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140580/
https://ncbi.nlm.nih.gov/pubmed/30228938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1470729
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