Phase 1b study targeting tumour associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer

BACKGROUND: Pancreatic ductal adenocarcinoma utilizes the CCL2/CCR2 chemokine axis to facilitate recruitment of tumor associated macrophages to sculpt an immunosuppressive tumor microenvironment. This pathway has prognostic implications in pancreas cancer, and blockade of CCR2 restores anti-tumor im...

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Bibliografiske detaljer
Udgivet i:Lancet Oncol
Main Authors: Nywening, Timothy M, Wang-Gillam, Andrea, Sanford, Dominic E, Belt, Brian A, Panni, Roheena Z, Cusworth, Brian M, Toriola, Adetunji T, Nieman, Rebecca K, Worley, Lori A, Yano, Motoyo, Fowler, Kathryn J, Lockhart, A Craig, Suresh, Rama, Tan, Benjamin R, Lim, Kian-Huat, Fields, Ryan C, Strasberg, Steven M, Hawkins, William G, DeNardo, David G, Goedegebuure, S Peter, Linehan, David C
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407285/
https://ncbi.nlm.nih.gov/pubmed/27055731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1470-2045(16)00078-4
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