A Study of Zoledronic Acid as Neo-Adjuvant, Perioperative Therapy in Patients with Resectable Pancreatic Ductal Adenocarcinoma

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by abundant granulocytic myeloid-derived suppressor cells (G-MDSC = CD45(+)/Lin(−)/CD33(+)/CD11b(+)/CD15(+)), which infiltrate tumors and suppress anti-tumor immunity. We have previously demonstrated in a m...

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Detalhes bibliográficos
Main Authors: Sanford, Dominic E., Porembka, Matthew R., Panni, Roheena Z., Mitchem, Jonathan B., Belt, Brian A., Plambeck-Suess, Stacey M., Lin, Goldie, DeNardo, David G., Fields, Ryan C., Hawkins, William G., Strasberg, Steven M., Lockhart, A. Craig, Wang-Gillam, Andrea, Goedegebuure, Simon Peter, Linehan, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786568/
https://ncbi.nlm.nih.gov/pubmed/24089656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/jct.2013.43096
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