Targeting both tumour-associated CXCR2(+) neutrophils and CCR2(+) macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

OBJECTIVE: Chemokine pathways are co-opted by pancreatic adenocarcinoma (PDAC) to facilitate myeloid cell recruitment from the bone marrow to establish an immunosuppressive tumour microenvironment (TME). Targeting tumour-associated CXCR2(+)neutrophils (TAN) or tumour-associated CCR2(+) macrophages (...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Nywening, Timothy M, Belt, Brian A, Cullinan, Darren R, Panni, Roheena Z, Han, Booyeon J, Sanford, Dominic E, Jacobs, Ryan C, Ye, Jian, Patel, Ankit A, Gillanders, William E, Fields, Ryan C, DeNardo, David G, Hawkins, William G, Goedegebuure, Peter, Linehan, David C
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2018
Assuntos:
Pancreas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5969359/
https://ncbi.nlm.nih.gov/pubmed/29196437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2017-313738
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