Decreased mitochondrial tRNALys steady-state levels and aminoacylation are associated with the pathogenic G8313A mitochondrial DNA mutation.

Por Bacman, Sandra R, Atencio, David P, Moraes, Carlos T
Publicado em 2003

Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

Por Bacman, Sandra R., Williams, Sion L., Moraes, Carlos T.
Publicado em 2009

Manipulating mitochondrial genomes in the clinic: playing by different rules

Por Moraes, Carlos T., Bacman, Sandra R., Williams, Sion L.
Publicado no Trends Cell Biol (2014)

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

Por Bacman, Sandra R., Williams, Sion L., Garcia, Sofia, Moraes, Carlos T.
Publicado em 2010

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria targeted restriction endonuclease

Por Bacman, Sandra R., Williams, Sion L., Duan, Dongsheng, Moraes, Carlos T.
Publicado em 2011

The Use of Mitochondria-Targeted Endonucleases to Manipulate mtDNA

Por Bacman, Sandra R., Williams, Sion L., Pinto, Milena, Moraes, Carlos T.
Publicado no Methods Enzymol (2014)

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Por Nissanka, Nadee, Bacman, Sandra R., Plastini, Melanie J., Moraes, Carlos T.
Publicado no Nat Commun (2018)

Specific elimination of mutant mitochondrial genomes in patient–derived cells by mitoTALENs

Por Bacman, Sandra R., Williams, Siôn L., Pinto, Milena, Peralta, Susana, Moraes, Carlos T.
Publicado em 2013

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

Por Hashimoto, Masami, Bacman, Sandra R, Peralta, Susana, Falk, Marni J, Chomyn, Anne, Chan, David C, Williams, Sion L, Moraes, Carlos T
Publicado no Mol Ther (2015)

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner

Por Pinto, Milena, Pickrell, Alicia M, Wang, Xiao, Bacman, Sandra R, Yu, Aixin, Hida, Aline, Dillon, Lloye M, Morton, Paul D, Malek, Thomas R, Williams, Siôn L, Moraes, Carlos T
Publicado no Cell Death Differ (2017)

Selective elimination of mitochondrial mutations in the germline by genome editing

Por Reddy, Pradeep, Ocampo, Alejandro, Suzuki, Keiichiro, Luo, Jinping, Bacman, Sandra R., Williams, Sion L., Sugawara, Atsushi, Okamura, Daiji, Tsunekawa, Yuji, Wu, Jun, Lam, David, Xiong, Xiong, Montserrat, Nuria, Esteban, Concepcion Rodriguez, Liu, Guang-Hui, Sancho-Martinez, Ignacio, Manau, Dolors, Civico, Salva, Cardellach, Francesc, O’Callaghan, Maria del Mar, Campistol, Jaime, Zhao, Huimin, Campistol, Josep Maria, Moraes, Carlos T., Belmonte, Juan Carlos Izpisua
Publicado no Cell (2015)