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Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria targeted restriction endonuclease
Mitochondrial diseases are frequently caused by heteroplasmic mtDNA mutations. Because these mutations express themselves only at high relative ratios, any approach able to manipulate mtDNA heteroplasmy can potentially be curative. In this study we developed a system to manipulate mtDNA heteroplasmy...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3410960/ https://ncbi.nlm.nih.gov/pubmed/22130448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2011.196 |
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