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Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a ‘differential multiple cleavage-site’ model

The ability to manipulate mitochondrial DNA (mtDNA) heteroplasmy would provide a powerful tool to treat mitochondrial diseases. Recent studies showed that mitochondria-targeted restriction endonucleases can modify mtDNA heteroplasmy in a predictable and efficient manner if it recognizes a single sit...

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Bibliografische gegevens
Hoofdauteurs: Bacman, SR, Williams, SL, Hernandez, D, Moraes, CT
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771437/
https://ncbi.nlm.nih.gov/pubmed/17597792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.gt.3302981
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