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Current strategies towards therapeutic manipulation of mtDNA heteroplasmy
Mitochondrial disease is a multifactorial disorder involving both nuclear and mitochondrial genomes. Over the past 20 years, great progress was achieved in the field of gene editing which raised the possibility of partial or complete elimination of mutant mtDNA that causes disease phenotypes. Each c...
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| Publicado en: | Front Biosci (Landmark Ed) |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6986768/ https://ncbi.nlm.nih.gov/pubmed/27814659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2741/4529 |
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