Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

mtDNA is present in multiple copies in each cell derived from the expansions of those in the oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, paternal mtDNA leakage, and novel medical technologies aiming to prevent inheritance of mtDNA-linked diseases. Heteroplasmy...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Latorre-Pellicer, Ana, Lechuga-Vieco, Ana Victoria, Johnston, Iain G., Hämäläinen, Riikka H., Pellico, Juan, Justo-Méndez, Raquel, Fernández-Toro, Jose María, Clavería, Cristina, Guaras, Adela, Sierra, Rocío, Llop, Jordi, Torres, Miguel, Criado, Luis Miguel, Suomalainen, Anu, Jones, Nick S., Ruíz-Cabello, Jesús, Enríquez, José Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899444/
https://ncbi.nlm.nih.gov/pubmed/31588014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.09.007
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