Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

mtDNA is present in multiple copies in each cell derived from the expansions of those in the oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, paternal mtDNA leakage, and novel medical technologies aiming to prevent inheritance of mtDNA-linked diseases. Heteroplasmy...

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Bibliographic Details
Published in:Cell Metab
Main Authors: Latorre-Pellicer, Ana, Lechuga-Vieco, Ana Victoria, Johnston, Iain G., Hämäläinen, Riikka H., Pellico, Juan, Justo-Méndez, Raquel, Fernández-Toro, Jose María, Clavería, Cristina, Guaras, Adela, Sierra, Rocío, Llop, Jordi, Torres, Miguel, Criado, Luis Miguel, Suomalainen, Anu, Jones, Nick S., Ruíz-Cabello, Jesús, Enríquez, José Antonio
Format: Artigo
Language:Inglês
Published: Cell Press 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899444/
https://ncbi.nlm.nih.gov/pubmed/31588014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.09.007
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