Regulation of Mother-to-Offspring Transmission of mtDNA Heteroplasmy

mtDNA is present in multiple copies in each cell derived from the expansions of those in the oocyte. Heteroplasmy, more than one mtDNA variant, may be generated by mutagenesis, paternal mtDNA leakage, and novel medical technologies aiming to prevent inheritance of mtDNA-linked diseases. Heteroplasmy...

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Pubblicato in:Cell Metab
Autori principali: Latorre-Pellicer, Ana, Lechuga-Vieco, Ana Victoria, Johnston, Iain G., Hämäläinen, Riikka H., Pellico, Juan, Justo-Méndez, Raquel, Fernández-Toro, Jose María, Clavería, Cristina, Guaras, Adela, Sierra, Rocío, Llop, Jordi, Torres, Miguel, Criado, Luis Miguel, Suomalainen, Anu, Jones, Nick S., Ruíz-Cabello, Jesús, Enríquez, José Antonio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899444/
https://ncbi.nlm.nih.gov/pubmed/31588014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.09.007
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