Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specifi...

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Publicado no:Sci Adv
Main Authors: Lechuga-Vieco, Ana Victoria, Latorre-Pellicer, Ana, Johnston, Iain G., Prota, Gennaro, Gileadi, Uzi, Justo-Méndez, Raquel, Acín-Pérez, Rebeca, Martínez-de-Mena, Raquel, Fernández-Toro, Jose María, Jimenez-Blasco, Daniel, Mora, Alfonso, Nicolás-Ávila, Jose A., Santiago, Demetrio J., Priori, Silvia G., Bolaños, Juan Pedro, Sabio, Guadalupe, Criado, Luis Miguel, Ruíz-Cabello, Jesús, Cerundolo, Vincenzo, Jones, Nick S., Enríquez, José Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439646/
https://ncbi.nlm.nih.gov/pubmed/32832682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba5345
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