Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics

Heteroplasmy, multiple variants of mitochondrial DNA (mtDNA) in the same cytoplasm, may be naturally generated by mutations but is counteracted by a genetic mtDNA bottleneck during oocyte development. Engineered heteroplasmic mice with nonpathological mtDNA variants reveal a nonrandom tissue-specifi...

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發表在:Sci Adv
Main Authors: Lechuga-Vieco, Ana Victoria, Latorre-Pellicer, Ana, Johnston, Iain G., Prota, Gennaro, Gileadi, Uzi, Justo-Méndez, Raquel, Acín-Pérez, Rebeca, Martínez-de-Mena, Raquel, Fernández-Toro, Jose María, Jimenez-Blasco, Daniel, Mora, Alfonso, Nicolás-Ávila, Jose A., Santiago, Demetrio J., Priori, Silvia G., Bolaños, Juan Pedro, Sabio, Guadalupe, Criado, Luis Miguel, Ruíz-Cabello, Jesús, Cerundolo, Vincenzo, Jones, Nick S., Enríquez, José Antonio
格式: Artigo
語言:Inglês
出版: American Association for the Advancement of Science 2020
主題:
Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7439646/
https://ncbi.nlm.nih.gov/pubmed/32832682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba5345
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