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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions

Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease function of the mtDNA polymerase gamma (POLG) is required for thi...

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Pubblicato in:Nat Commun
Autori principali: Nissanka, Nadee, Bacman, Sandra R., Plastini, Melanie J., Moraes, Carlos T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021392/
https://ncbi.nlm.nih.gov/pubmed/29950568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04895-1
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