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The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
Double-strand breaks in the mitochondrial DNA (mtDNA) result in the formation of linear fragments that are rapidly degraded. However, the identity of the nuclease(s) performing this function is not known. We found that the exonuclease function of the mtDNA polymerase gamma (POLG) is required for thi...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6021392/ https://ncbi.nlm.nih.gov/pubmed/29950568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04895-1 |
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