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Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches
Mitochondrial DNA (mtDNA) encodes a subset of the genes which are responsible for oxidative phosphorylation. Pathogenic mutations in the human mtDNA are often heteroplasmic, where wild‐type mtDNA species co‐exist with the pathogenic mtDNA and a bioenergetic defect is only seen when the pathogenic mt...
Guardat en:
| Publicat a: | EMBO Rep |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
John Wiley and Sons Inc.
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7054667/ https://ncbi.nlm.nih.gov/pubmed/32073748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949612 |
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