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Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches

Mitochondrial DNA (mtDNA) encodes a subset of the genes which are responsible for oxidative phosphorylation. Pathogenic mutations in the human mtDNA are often heteroplasmic, where wild‐type mtDNA species co‐exist with the pathogenic mtDNA and a bioenergetic defect is only seen when the pathogenic mt...

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Dades bibliogràfiques
Publicat a:EMBO Rep
Autors principals: Nissanka, Nadee, Moraes, Carlos T
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054667/
https://ncbi.nlm.nih.gov/pubmed/32073748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949612
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