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Mitochondrial DNA heteroplasmy in disease and targeted nuclease‐based therapeutic approaches
Mitochondrial DNA (mtDNA) encodes a subset of the genes which are responsible for oxidative phosphorylation. Pathogenic mutations in the human mtDNA are often heteroplasmic, where wild‐type mtDNA species co‐exist with the pathogenic mtDNA and a bioenergetic defect is only seen when the pathogenic mt...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7054667/ https://ncbi.nlm.nih.gov/pubmed/32073748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949612 |
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