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Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks

To investigate mtDNA recombination induced by multiple double strand breaks (DSBs) we used a mitochondria-targeted form of the ScaI restriction endonuclease to introduce DSBs in heteroplasmic mice and cells in which we were able to utilize haplotype differences to trace the origin of recombined mole...

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Detalhes bibliográficos
Main Authors: Bacman, Sandra R., Williams, Sion L., Moraes, Carlos T.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715231/
https://ncbi.nlm.nih.gov/pubmed/19435881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp348
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