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Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks
To investigate mtDNA recombination induced by multiple double strand breaks (DSBs) we used a mitochondria-targeted form of the ScaI restriction endonuclease to introduce DSBs in heteroplasmic mice and cells in which we were able to utilize haplotype differences to trace the origin of recombined mole...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2715231/ https://ncbi.nlm.nih.gov/pubmed/19435881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp348 |
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