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Decreased mitochondrial tRNALys steady-state levels and aminoacylation are associated with the pathogenic G8313A mitochondrial DNA mutation.

Mutations in human mitochondrial tRNA genes cause a number of multisystemic disorders. A G-to-A transition at position 8313 (G8313A) transition in the mitochondrial tRNALys gene has been associated with a childhood syndrome characterized by gastrointestinal-system involvement and encephaloneuropathy...

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Detalhes bibliográficos
Main Authors: Bacman, Sandra R, Atencio, David P, Moraes, Carlos T
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223569/
https://ncbi.nlm.nih.gov/pubmed/12737626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030222
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