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Specific elimination of mutant mitochondrial genomes in patient–derived cells by mitoTALENs
Mitochondrial diseases are commonly caused by mutations in the mitochondrial DNA (mtDNA), which in most cases co–exists with the wild–type (mtDNA heteroplasmy). We have engineered TAL–effector nucleases (TALENs) to localize to mitochondria and cleave different classes of pathogenic mtDNA mutations....
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4153471/ https://ncbi.nlm.nih.gov/pubmed/23913125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3261 |
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