Assessment of the optimization of affinity and specificity at protein–DNA interfaces

por Ashworth, Justin, Baker, David
Publicado 2009

Reverse engineering systems models of regulation: discovery, prediction and mechanisms

por Ashworth, Justin, Wurtmann, Elisabeth J, Baliga, Nitin S
Publicado 2011

Inference of Expanded Lrp-Like Feast/Famine Transcription Factor Targets in a Non-Model Organism Using Protein Structure-Based Prediction

por Ashworth, Justin, Plaisier, Christopher L., Lo, Fang Yin, Reiss, David J., Baliga, Nitin S.
Publicado 2014

Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers

por Ashworth, Justin, Bernard, Brady, Reynolds, Sheila, Plaisier, Christopher L., Shmulevich, Ilya, Baliga, Nitin S.
Publicado en Nucleic Acids Res (2014)

Genome-wide diel growth state transitions in the diatom Thalassiosira pseudonana

por Ashworth, Justin, Coesel, Sacha, Lee, Allison, Armbrust, E. Virginia, Orellana, Mónica V., Baliga, Nitin S.
Publicado 2013

Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs

por Ashworth, Justin, Taylor, Gregory K., Havranek, James J., Quadri, S. Arshiya, Stoddard, Barry L., Baker, David
Publicado 2010

Overexpression of Key Sterol Pathway Enzymes in Two Model Marine Diatoms Alters Sterol Profiles in Phaeodactylum tricornutum

por Jaramillo-Madrid, Ana Cristina, Abbriano, Raffaela, Ashworth, Justin, Fabris, Michele, Pernice, Mathieu, Ralph, Peter J.
Publicado en Pharmaceuticals (Basel) (2020)

Thermodynamics of DNA target site recognition by homing endonucleases

por Eastberg, Jennifer H., Smith, Audrey McConnell, Zhao, Lei, Ashworth, Justin, Shen, Betty W., Stoddard, Barry L.
Publicado 2007

Computational redesign of endonuclease DNA binding and cleavage specificity

por Ashworth, Justin, Havranek, James J., Duarte, Carlos M., Sussman, Django, Monnat, Raymond J., Stoddard, Barry L., Baker, David
Publicado 2006

Exploitation of binding energy for catalysis and design

por Thyme, Summer B., Jarjour, Jordan, Takeuchi, Ryo, Havranek, James J., Ashworth, Justin, Scharenberg, Andrew M., Stoddard, Barry L., Baker, David
Publicado 2009

Reprogramming homing endonuclease specificity through computational design and directed evolution

por Thyme, Summer B., Boissel, Sandrine J. S., Arshiya Quadri, S., Nolan, Tony, Baker, Dean A., Park, Rachel U., Kusak, Lara, Ashworth, Justin, Baker, David
Publicado 2014

Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics

por Bateman, Raynard L., Ashworth, Justin, Witte, John F., Baker, L.-J., Bhanumoorthy, Pullooru, Timm, David E., Hurley, Thomas D., Grompe, Markus, Mcclard, Ronald W.
Publicado 2007

Evolution of context dependent regulation by expansion of feast/famine regulatory proteins

por Plaisier, Christopher L, Lo, Fang-Yin, Ashworth, Justin, Brooks, Aaron N, Beer, Karlyn D, Kaur, Amardeep, Pan, Min, Reiss, David J, Facciotti, Marc T, Baliga, Nitin S
Publicado en BMC Syst Biol (2014)

RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite

por Fleishman, Sarel J., Leaver-Fay, Andrew, Corn, Jacob E., Strauch, Eva-Maria, Khare, Sagar D., Koga, Nobuyasu, Ashworth, Justin, Murphy, Paul, Richter, Florian, Lemmon, Gordon, Meiler, Jens, Baker, David
Publicado 2011

Genomic architecture of inflammatory bowel disease in five families with multiple affected individuals

por Stittrich, Anna B, Ashworth, Justin, Shi, Mude, Robinson, Max, Mauldin, Denise, Brunkow, Mary E, Biswas, Shameek, Kim, Jin-Man, Kwon, Ki-Sun, Jung, Jae U, Galas, David, Serikawa, Kyle, Duerr, Richard H, Guthery, Stephen L, Peschon, Jacques, Hood, Leroy, Roach, Jared C, Glusman, Gustavo
Publicado en Hum Genome Var (2016)

Mutations in NOTCH1 Cause Adams-Oliver Syndrome

por Stittrich, Anna-Barbara, Lehman, Anna, Bodian, Dale L., Ashworth, Justin, Zong, Zheyuan, Li, Hong, Lam, Patricia, Khromykh, Alina, Iyer, Ramaswamy K., Vockley, Joseph G., Baveja, Rajiv, Silva, Ermelinda Santos, Dixon, Joanne, Leon, Eyby L., Solomon, Benjamin D., Glusman, Gustavo, Niederhuber, John E., Roach, Jared C., Patel, Millan S.
Publicado 2014

Rare variants in neuronal excitability genes influence risk for bipolar disorder

por Ament, Seth A., Szelinger, Szabolcs, Glusman, Gustavo, Ashworth, Justin, Hou, Liping, Akula, Nirmala, Shekhtman, Tatyana, Badner, Judith A., Brunkow, Mary E., Mauldin, Denise E., Stittrich, Anna-Barbara, Rouleau, Katherine, Detera-Wadleigh, Sevilla D., Nurnberger, John I., Edenberg, Howard J., Gershon, Elliot S., Schork, Nicholas, Price, Nathan D., Gelinas, Richard, Hood, Leroy, Craig, David, McMahon, Francis J., Kelsoe, John R., Roach, Jared C., Kelsoe, John R., Greenwood, Tiffany A., Nievergelt, Caroline M., Shilling, Paul D., Shekhtman, Tatyana, Roach, Jared C., Ament, Seth A., Hood, Leroy, Nurnberger, John I., Edenberg, Howard J., Foroud, Tatiana, Koller, Daniel L., Gershon, Elliot S., Badner, Judith A., Liu, Chunyu, Scheftner, William A., Lawson, William B., Coryell, William, Potash, James B., Rice, John, Byerley, William, McMahon, Francis J., Hou, Liping, Berrettini, Wade H., Zandi, Peter P., McInnis, Melvin G., Craig, David W., Szelinger, Szabolcs, Schulze, Thomas G., Schork, Nicholas J., Quarless, Danjuma
Publicado en Proc Natl Acad Sci U S A (2015)