Reprogramming homing endonuclease specificity through computational design and directed evolution

Homing endonucleases (HEs) can be used to induce targeted genome modification to reduce the fitness of pathogen vectors such as the malaria-transmitting Anopheles gambiae and to correct deleterious mutations in genetic diseases. We describe the creation of an extensive set of HE variants with novel...

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Bibliographic Details
Main Authors:	Thyme, Summer B., Boissel, Sandrine J. S., Arshiya Quadri, S., Nolan, Tony, Baker, Dean A., Park, Rachel U., Kusak, Lara, Ashworth, Justin, Baker, David
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2014
Subjects:	Nucleic Acid Enzymes
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3936771/ https://ncbi.nlm.nih.gov/pubmed/24270794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1212
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Reprogramming homing endonuclease specificity through computational design and directed evolution

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