Reprogramming homing endonuclease specificity through computational design and directed evolution

Homing endonucleases (HEs) can be used to induce targeted genome modification to reduce the fitness of pathogen vectors such as the malaria-transmitting Anopheles gambiae and to correct deleterious mutations in genetic diseases. We describe the creation of an extensive set of HE variants with novel...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Thyme, Summer B., Boissel, Sandrine J. S., Arshiya Quadri, S., Nolan, Tony, Baker, Dean A., Park, Rachel U., Kusak, Lara, Ashworth, Justin, Baker, David
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936771/
https://ncbi.nlm.nih.gov/pubmed/24270794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1212
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi