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Reprogramming homing endonuclease specificity through computational design and directed evolution

Homing endonucleases (HEs) can be used to induce targeted genome modification to reduce the fitness of pathogen vectors such as the malaria-transmitting Anopheles gambiae and to correct deleterious mutations in genetic diseases. We describe the creation of an extensive set of HE variants with novel...

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Detalhes bibliográficos
Main Authors: Thyme, Summer B., Boissel, Sandrine J. S., Arshiya Quadri, S., Nolan, Tony, Baker, Dean A., Park, Rachel U., Kusak, Lara, Ashworth, Justin, Baker, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936771/
https://ncbi.nlm.nih.gov/pubmed/24270794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1212
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