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Reprogramming homing endonuclease specificity through computational design and directed evolution
Homing endonucleases (HEs) can be used to induce targeted genome modification to reduce the fitness of pathogen vectors such as the malaria-transmitting Anopheles gambiae and to correct deleterious mutations in genetic diseases. We describe the creation of an extensive set of HE variants with novel...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936771/ https://ncbi.nlm.nih.gov/pubmed/24270794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1212 |
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