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Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
Site-specific homing endonucleases are capable of inducing gene conversion via homologous recombination. Reprogramming their cleavage specificities allows the targeting of specific biological sites for gene correction or conversion. We used computational protein design to alter the cleavage specific...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938204/ https://ncbi.nlm.nih.gov/pubmed/20435674 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq283 |
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