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Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
LAGLIDADG homing endonucleases (LHEs) are compact endonucleases with 20–22 bp recognition sites, and thus are ideal scaffolds for engineering site-specific DNA cleavage enzymes for genome editing applications. Here, we describe a general approach to LHE engineering that combines rational design with...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2014
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4041414/ https://ncbi.nlm.nih.gov/pubmed/24682825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku224 |
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