Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics

FAH (fumarylacetoacetate hydrolase) catalyses the final step of tyrosine catabolism to produce fumarate and acetoacetate. HT1 (hereditary tyrosinaemia type 1) results from deficiency of this enzyme. Previously, we prepared a partial mimic of the putative tetrahedral intermediate in the reaction cata...

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Detalhes bibliográficos
Main Authors: Bateman, Raynard L., Ashworth, Justin, Witte, John F., Baker, L.-J., Bhanumoorthy, Pullooru, Timm, David E., Hurley, Thomas D., Grompe, Markus, Mcclard, Ronald W.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798426/
https://ncbi.nlm.nih.gov/pubmed/17064256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060961
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