In Vivo Selection of Transplanted Hepatocytes by Pharmacological Inhibition of Fumarylacetoacetate Hydrolase in Wild-type Mice

Genetic fumarylacetoacetate hydrolase (Fah) deficiency is unique in that healthy gene-corrected hepatocytes have a strong growth advantage and can repopulate the diseased liver. Unfortunately, similar positive selection of gene-corrected cells is absent in most inborn errors of liver metabolism and...

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Main Authors: Paulk, Nicole K, Wursthorn, Karsten, Haft, Annelise, Pelz, Carl, Clarke, Gregory, Newell, Amy H, Olson, Susan B, Harding, Cary O, Finegold, Milton J, Bateman, Raymond L, Witte, John F, McClard, Ronald, Grompe, Markus
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464641/
https://ncbi.nlm.nih.gov/pubmed/22871666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.154
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