In Vivo Selection of Transplanted Hepatocytes by Pharmacological Inhibition of Fumarylacetoacetate Hydrolase in Wild-type Mice

Genetic fumarylacetoacetate hydrolase (Fah) deficiency is unique in that healthy gene-corrected hepatocytes have a strong growth advantage and can repopulate the diseased liver. Unfortunately, similar positive selection of gene-corrected cells is absent in most inborn errors of liver metabolism and...

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Главные авторы: Paulk, Nicole K, Wursthorn, Karsten, Haft, Annelise, Pelz, Carl, Clarke, Gregory, Newell, Amy H, Olson, Susan B, Harding, Cary O, Finegold, Milton J, Bateman, Raymond L, Witte, John F, McClard, Ronald, Grompe, Markus
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464641/
https://ncbi.nlm.nih.gov/pubmed/22871666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.154
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