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Low Therapeutic Threshold for Hepatocyte Replacement in Murine Phenylketonuria
Phenylalanine homeostasis in mammals is primarily controlled by liver phenylalanine hydroxylase (PAH) activity. Inherited PAH deficiency (phenylketonuria or PKU) leads to hyperphenylalaninemia in both mice and humans. A low level of residual liver PAH activity ensures near-normal dietary protein tol...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2694052/ https://ncbi.nlm.nih.gov/pubmed/16043102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2005.03.025 |
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