Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics

FAH (fumarylacetoacetate hydrolase) catalyses the final step of tyrosine catabolism to produce fumarate and acetoacetate. HT1 (hereditary tyrosinaemia type 1) results from deficiency of this enzyme. Previously, we prepared a partial mimic of the putative tetrahedral intermediate in the reaction cata...

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Autori principali: Bateman, Raynard L., Ashworth, Justin, Witte, John F., Baker, L.-J., Bhanumoorthy, Pullooru, Timm, David E., Hurley, Thomas D., Grompe, Markus, Mcclard, Ronald W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1798426/
https://ncbi.nlm.nih.gov/pubmed/17064256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060961
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