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Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers
Thousands of unique mutations in transcription factors (TFs) arise in cancers, and the functional and biological roles of relatively few of these have been characterized. Here, we used structure-based methods developed specifically for DNA-binding proteins to systematically predict the consequences...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245936/ https://ncbi.nlm.nih.gov/pubmed/25378323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1031 |
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