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Structure-based predictions broadly link transcription factor mutations to gene expression changes in cancers
Thousands of unique mutations in transcription factors (TFs) arise in cancers, and the functional and biological roles of relatively few of these have been characterized. Here, we used structure-based methods developed specifically for DNA-binding proteins to systematically predict the consequences...
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| Publicado no: | Nucleic Acids Res |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4245936/ https://ncbi.nlm.nih.gov/pubmed/25378323 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1031 |
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