Rare variants in neuronal excitability genes influence risk for bipolar disorder

We sequenced the genomes of 200 individuals from 41 families multiply affected with bipolar disorder (BD) to identify contributions of rare variants to genetic risk. We initially focused on 3,087 candidate genes with known synaptic functions or prior evidence from genome-wide association studies. BD...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ament, Seth A., Szelinger, Szabolcs, Glusman, Gustavo, Ashworth, Justin, Hou, Liping, Akula, Nirmala, Shekhtman, Tatyana, Badner, Judith A., Brunkow, Mary E., Mauldin, Denise E., Stittrich, Anna-Barbara, Rouleau, Katherine, Detera-Wadleigh, Sevilla D., Nurnberger, John I., Edenberg, Howard J., Gershon, Elliot S., Schork, Nicholas, Price, Nathan D., Gelinas, Richard, Hood, Leroy, Craig, David, McMahon, Francis J., Kelsoe, John R., Roach, Jared C., Greenwood, Tiffany A., Nievergelt, Caroline M., Shilling, Paul D., Foroud, Tatiana, Koller, Daniel L., Liu, Chunyu, Scheftner, William A., Lawson, William B., Coryell, William, Potash, James B., Rice, John, Byerley, William, Berrettini, Wade H., Zandi, Peter P., McInnis, Melvin G., Craig, David W., Schulze, Thomas G., Schork, Nicholas J., Quarless, Danjuma
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371952/
https://ncbi.nlm.nih.gov/pubmed/25730879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424958112
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