PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

Por Flaiz, C, Chernoff, J, Ammoun, S, Peterson, JR, Hanemann, CO
Publicado em 2009

Nilotinib alone or in combination with selumetinib is a drug candidate for neurofibromatosis type 2

Por Ammoun, Sylwia, Schmid, Marei Caroline, Triner, Joceline, Manley, Paul, Hanemann, Clemens Oliver
Publicado em 2011

Merlin-Deficient Human Tumors Show Loss of Contact Inhibition and Activation of Wnt/β-Catenin Signaling Linked to the PDGFR/Src and Rac/PAK Pathways

Por Zhou, Lu, Ercolano, Emanuela, Ammoun, Sylwia, Schmid, M Caroline, Barczyk, Magdalena A, Hanemann, Clemens Oliver
Publicado em 2011

The p53/mouse double minute 2 homolog complex deregulation in merlin‐deficient tumours

Por Ammoun, Sylwia, Schmid, Marei Caroline, Zhou, Lu, Hilton, David A., Barczyk, Magdalena, Hanemann, Clemens Oliver
Publicado no Mol Oncol (2014)

An essential role for the tumor suppressor Merlin in regulating fatty acid synthesis

Por Stepanova, Dina S., Semenova, Galina, Kuo, Yin-Ming, Andrews, Andrew J., Ammoun, Sylwia, Hanemann, C. O., Chernoff, Jonathan
Publicado no Cancer Res (2017)

ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma(†)

Por Ammoun, Sylwia, Cunliffe, Clare H., Allen, Jeffrey C., Chiriboga, Luis, Giancotti, Filippo G., Zagzag, David, Hanemann, C. Oliver, Karajannis, Matthias A.
Publicado em 2010

PP03. HUMAN ENDOGENOUS RETROVIRUS TYPE K (HERVK) PROTEINS ARE OVEREXPRESSED AND RELEASED FROM HUMAN PRIMARY SCHWANNOMA CELLS CONTRIBUTING TO TUMOUR DEVELOPMENT VIA ERK, AKT, FAK PA...

Por Ammoun, Dr Sylwia, Maze, Mr Emmanuel, Reeves, Ms Shona, Hilton, Dr David, Ercolano, Dr Emanuela, Hamemann, Prof Oliver, Belshaw, Dr Robert
Publicado no Neuro Oncol (2017)

The Scaffold Protein KSR1, A Novel Therapeutic Target for the Treatment of Merlin-Deficient Tumors

Por Zhou, Lu, Lyons-Rimmer, Jade, Ammoun, Sylwia, Müller, Jürgen, Lasonder, Edwin, Sharma, Vikram, Ercolano, Emanuela, Hilton, David, Taiwo, Ifeoluwatola, Barczyk, Magdalena, Hanemann, C. Oliver
Publicado no Oncogene (2015)

CTF Meeting 2012: Translation of the Basic Understanding of the Biology and Genetics of NF1, NF2, and Schwannomatosis Toward the Development of Effective Therapies

Por Widemann, Brigitte C., Acosta, Maria T., Ammoun, Sylvia, Belzberg, Allan J., Bernards, Andre, Blakeley, Jaishri, Bretscher, Antony, Cichowski, Karen, Clapp, D. Wade, Dombi, Eva, Evans, Gareth D., Ferner, Rosalie, Fernandez-Valle, Cristina, Fisher, Michael J., Giovannini, Marco, Gutmann, David H., Hanemann, C. Oliver, Hennigan, Robert, Huson, Susan, Ingram, David, Kissil, Joe, Korf, Bruce R., Legius, Eric, Packer, Roger J., McClatchey, Andrea I, McCormick, Frank, North, Kathryn, Pehrsson, Minja, Plotkin, Scott R., Ramesh, Vijaya, Ratner, Nancy, Schirmer, Susann, Sherman, Larry, Schorry, Elizabeth, Stevenson, David, Stewart, Douglas R., Ullrich, Nicole, Bakker, Annette C., Morrison, Helen
Publicado em 2014