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PAK kinase regulates Rac GTPase and is a potential target in human schwannomas
Merlin loss causes benign tumours of the nervous system, mainly schwannomas and meningiomas. Schwannomas show enhanced Rac1 and Cdc42 activity, The p21-activated kinase 2 (PAK2) activation and increased ruffling and cell adhesion. PAK regulates activation of merlin. PAK has been proposed as a potent...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2760977/ https://ncbi.nlm.nih.gov/pubmed/19409384 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.04.019 |
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