Pak and Rac GTPases promote oncogenic KIT–induced neoplasms

An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this mutation with an allosteric inhibitor of p21–activated kinase (Pak) or its...

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Hauptverfasser: Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R., Visconte, Valeria, Tiu, Ramon V., Vlaar, Cornelis P., Dharmawardhane, Suranganie, Kapur, Reuben
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784531/
https://ncbi.nlm.nih.gov/pubmed/24091327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67509
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