Pak and Rac GTPases promote oncogenic KIT–induced neoplasms

An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this mutation with an allosteric inhibitor of p21–activated kinase (Pak) or its...

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Main Authors: Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R., Visconte, Valeria, Tiu, Ramon V., Vlaar, Cornelis P., Dharmawardhane, Suranganie, Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784531/
https://ncbi.nlm.nih.gov/pubmed/24091327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67509
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