Pak and Rac GTPases promote oncogenic KIT–induced neoplasms

An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this mutation with an allosteric inhibitor of p21–activated kinase (Pak) or its...

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Detalhes bibliográficos
Main Authors: Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R., Visconte, Valeria, Tiu, Ramon V., Vlaar, Cornelis P., Dharmawardhane, Suranganie, Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784531/
https://ncbi.nlm.nih.gov/pubmed/24091327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67509
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