Pak and Rac GTPases promote oncogenic KIT–induced neoplasms

An acquired somatic mutation at codon 816 in the KIT receptor tyrosine kinase is associated with poor prognosis in patients with systemic mastocytosis and acute myeloid leukemia (AML). Treatment of leukemic cells bearing this mutation with an allosteric inhibitor of p21–activated kinase (Pak) or its...

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Main Authors: Martin, Holly, Mali, Raghuveer Singh, Ma, Peilin, Chatterjee, Anindya, Ramdas, Baskar, Sims, Emily, Munugalavadla, Veerendra, Ghosh, Joydeep, Mattingly, Ray R., Visconte, Valeria, Tiu, Ramon V., Vlaar, Cornelis P., Dharmawardhane, Suranganie, Kapur, Reuben
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2013
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784531/
https://ncbi.nlm.nih.gov/pubmed/24091327
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67509
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