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PAK kinase regulates Rac GTPase and is a potential target in human schwannomas

Merlin loss causes benign tumours of the nervous system, mainly schwannomas and meningiomas. Schwannomas show enhanced Rac1 and Cdc42 activity, The p21-activated kinase 2 (PAK2) activation and increased ruffling and cell adhesion. PAK regulates activation of merlin. PAK has been proposed as a potent...

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Hlavní autoři: Flaiz, C, Chernoff, J, Ammoun, S, Peterson, JR, Hanemann, CO
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760977/
https://ncbi.nlm.nih.gov/pubmed/19409384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2009.04.019
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