Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization

由 Harikumar, Kaleeckal G., Akgün, Eyup, Portoghese, Philip S., Miller, Laurence J.
出版 2010

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

由 Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
發表在 Eur J Pharmacol (2014)

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

由 Dutta, Raini, Lunzer, Mary M., Auger, Jennifer L., Akgün, Eyup, Portoghese, Philip S., Binstadt, Bryce A.
發表在 Arthritis Res Ther (2018)

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

由 Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Smeester, Branden A., Beitz, Al J., Portoghese, Philip S.
出版 2013

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

由 Aceto, Mario D., Harris, Louis S., Negus, S. Stevens, Banks, Matthew L., Hughes, Larry D., Akgün, Eyup, Portoghese, Philip S.
發表在 Int J Med Chem (2012)

Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

由 Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
出版 2013

INHIBITION OF INFLAMMATORY AND NEUROPATHIC PAIN BY TARGETING A MU OPIOID RECEPTOR/CHEMOKINE RECEPTOR5 HETEROMER (MOR-CCR(5))

由 Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Powers, Michael D., Sham, Yuk Y., Watanabe, Yoshikazu, Portoghese, Philip S.
發表在 J Med Chem (2015)

The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids

由 Speltz, Rebecca, Lunzer, Mary M., Shueb, Sarah S., Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S., Simone, Donald A.
發表在 Pain (2020)

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and 2 cholecystokinin receptors

由 Akgün, Eyup, Körner, Meike, Gao, Fan, Harkumar, Kaleeckal G., Waser, Beatrice, Reubi, Jean Claude, Portoghese, Philip S., Miller, Laurence J.
出版 2009

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK(2)) receptors by novel bivalent ligands

由 Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G., Hopson, Jessika, Powers, Michael D., Lunzer, Mary M., Miller, Laurence J., Portoghese, Philip S.
出版 2009

The Bivalent Ligand MCC22 Potently Attenuates Hyperalgesia in a Mouse Model of Cisplatin-Evoked Neuropathic Pain without Tolerance or Reward

由 Cataldo, Giuseppe, Erb, Samuel J., Lunzer, Mary M., Luong, Nhungoc, Akgün, Eyup, Portoghese, Philip S., Olson, Julie K., Simone, Donald A.
發表在 Neuropharmacology (2019)

Targeting MOR-mGluR(5) heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

由 Shueb, Sarah S., Erb, Samuel J., Lunzer, Mary M., Speltz, Rebecca, Harding-Rose, Catherine, Akgün, Eyup, Simone, Donald A., Portoghese, Philip S.
發表在 Neuropharmacology (2019)

The bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

由 Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.
發表在 Pain (2018)

The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice

由 Bruce, Daniel.J., Peterson, Cristina.D., Kitto, Kelley. F., Akgün, Eyup., Lazzaroni, Sophia., Portoghese, Phillip.S., Fairbanks, Carolyn. A., Wilcox, George. L.
發表在 Anesthesiology (2019)

A bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

由 Peterson, Cristina D., Kitto, Kelley F., Akgün, Eyup, Lunzer, Mary M., Riedl, Maureen S., Vulchanova, Lucy, Wilcox, George L., Portoghese, Philip S., Fairbanks, Carolyn A.
發表在 Pain (2017)

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor

由 Cawston, Erin E., Lam, Polo C. H., Harikumar, Kaleeckal G., Dong, Maoqing, Ball, Alicja M., Augustine, Mary Lou, Akgün, Eyup, Portoghese, Philip S., Orry, Andrew, Abagyan, Ruben, Sexton, Patrick M., Miller, Laurence J.
出版 2012